Medium chain polyphosphate small molecule (tool compound)

The medium chain polyphosphate is linear polymers of inorganic orthophosphate linked by high-energy phosphoanhydride bonds that has an approximate polymer length ranging from ~45-160 phosphate units. Polyphosphates are secreted from platelets to regulate blood clotting and have been used in plasma clotting assays and to study bacteria growth and function.

Contributors

Inventor Institute
James Morrissey University of Michigan
Product description: The medium chain polyphosphate is linear polymers of inorganic orthophosphate linked by high-energy phosphoanhydride bonds that has an approximate polymer length ranging from ~45-160 phosphate units. Polyphosphates are secreted from platelets to regulate blood clotting and have been used in plasma clotting assays and to study bacteria growth and function.
References:

Wang et al. 2019. J Thromb Haemost. :. PMID: 31420909.

Zilberman-Rudenko et al. 2018. Arterioscler Thromb Vasc Biol. 38(8):1748-1760. PMID: 30354195.

Wijeyewickrema et al. 2016. Blood. 128(13):1766-76. PMID: 27338096.

Choi et al. 2015. Thromb Haemost. 113(3):599-604. PMID: 25338662.

Puy et al. 2013. J Thromb Haemost. 11(7):1341-52. PMID: 23659638.

Smith et al. 2012. Blood. 120(26):5103-10. PMID: 22968458.

Choi et al. 2011. Blood. 118(26):6963-70. PMID: 21976677.

Smith et al. 2010. Blood. 116(20):4353-9. PMID: 20709905.

Choi et al. 2010. Biochemistry. 49(45):9935-41. PMID: 20957999.

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