AzaPc quencher small molecule (tool compound)

AzaPc shows a significantly higher quenching efficiency compared to the commercially available dark quenchers (BHQ-1, BHQ-2, BBQ-650) in a developed model of TaqMan PCR assay. The AzaPc-labeled probe proved to also be useful in a practical PCR assay for the quantification of the SLCO2B1 transporter gene expression. The constructed calibration curves indicated linearity in the range from 102 to 107 of target copies. -From Demuth et al 2018, PMID: 29683215

Contributors

Inventor Institute
Petr Zim?í­k ; Miroslav Miletí­n Charles University
Product description: Unsymmetrical dialkylamino‐substituted zinc azaphthalocyanine (AzaPc) exhibits unique spectral and photophysical properties for dark quenchers of fluorescence in DNA hybridization probes. The panchromatic light absorption of AzaPc from 300 nm up to at least 700 nm and its lack of fluorescence make it an ideal candidate for a universal dark quencher. -From Demuth et al 2018, PMID: 29683215
References:

Demuth et al. 2020. Chempluschem. 85(3):527-537. PMID: 32187858.

Demuth et al. 2018. Chemistry. 24(38):9658-9666. PMID: 29683215.

Scheper et al. 2011. Autophagy. 7(8):910-1. PMID: 21494086.

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