Western blot analysis comparing binding to murine and human MTBP. 30ug H1299 protein/well. Mouse antibodies were at a concentration of 3ug/ml. AS-1 rabbit 1

Anti-MTBP [2C1E11] Product

MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 […]

TOV-3041G cell line Product

[…] where a somatic TP53 mutation was not detected by mutation screening. However, the absense of p53 mRNA and protein in addition to impaired p53 function was detected in this line. […]

Caov-3 Cell Line Product

[…] CA-125, Ba-2, and Ca-1 tumour-associated antigens. The Caov-3 cells harbour a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive […]

CAMA-1 Cell Line Product

[…] have an in-frame mutation in the E-cadherin gene, resulting in a truncated, non-functional protein. In addition, they have oncogenic mutations in PTEN and p53 and amplification of the cyclin D1 gene.

Capan-2 Cell line Product

[…] pancreatic cancer. The Capan-2 cells express mutant K-Ras (G12V) and elevated levels of the Epidermal Growth Factor Receptor (EGFR). In addition, they express wildtype p53 and normal levels of SMAD4 protein.

Capan-1 Cell line Product

[…] In addition, they have an oncogenic mutation in K-Ras (G12V) and an inactivating mutation in p53. These cells express elevated levels of the Epidermal Growth Factor Receptor (EGFR) and do […]

Head and neck cancer Page

[…] a favourable indicator of prognosis in some subsets of HNC. As well as antibodies for p53 and EGFR, as overexpression of EGFR and inhibition of p53 are commonly observed in […]