N_N20R1 Cell Line Product
The p53 mediated responses of the parental and resistant cell line were compared. In contrast to the parental cell lines, p53 activation by Nutlin-3, MI-63 or ionizing radiation was not […]
The p53 mediated responses of the parental and resistant cell line were compared. In contrast to the parental cell lines, p53 activation by Nutlin-3, MI-63 or ionizing radiation was not […]
melan-p53-2 cells are immortal melanocyte cell lines derived from the skin of neonatal Tp53–/– C57BL/6J mice
Rabbit anti-human p53 polyclonal recognises a 53kDa cytoplasmic/nuclear protein up regulated in response to DNA damage.
Monoclonal antibody directed against p53, binding a distinct epitope in amino acids 18-27 at the N-terminus
To determine how resistance to MDM2/ p53 binding antagonists might develop, SJSA-1 cells were exposed to growth inhibitory concentrations of a MDM2 inhibitor, MI-63, and a clonal resistant cell line […]
[…] cancer are often known oncogenes or tumour suppressors. These include transcription factors such as MYC, MYB, p53, STAT3, nuclear factor-κB (NF-κB), and fusion transcription factors frequently associated with paediatric cancers. The RAS family also belong to these proteins, […]
p53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as […]
PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.
MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 […]
MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 […]
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