N_N20R1 Cell Line Product

The p53 mediated responses of the parental and resistant cell line were compared. In contrast to the parental cell lines, p53 activation by Nutlin-3, MI-63 or ionizing radiation was not […]

Melan-p53-2 cell line Product

melan-p53-2 cells are immortal melanocyte cell lines derived from the skin of neonatal Tp53–/– C57BL/6J mice

Anti-p53 Product

Rabbit anti-human p53 polyclonal recognises a 53kDa cytoplasmic/nuclear protein up regulated in response to DNA damage.

Anti-p53 [PAb242] Product

Monoclonal antibody directed against p53, binding a distinct epitope in amino acids 18-27 at the N-terminus

S_M6R1 Cell Line Product

To determine how resistance to MDM2/ p53 binding antagonists might develop, SJSA-1 cells were exposed to growth inhibitory concentrations of a MDM2 inhibitor, MI-63, and a clonal resistant cell line […]

Investigating undruggable targets in cancer research Blog Post

[…] cancer are often known oncogenes or tumour suppressors. These include transcription factors such as MYC, MYB, p53, STAT3, nuclear factor-κB (NF-κB), and fusion transcription factors frequently associated with paediatric cancers. The RAS family also belong to these proteins, […]

Immunohistochemistry using anti-p53 [V5P4H6*B3] on a Zebrafish embryo.

Anti-p53 [V5P4H6*B3] Product

p53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as […]

Anti-p53 [Pab 1104] Product

PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.

Western blot analysis comparing binding to murine and human MTBP. 30ug H1299 protein/well. Mouse antibodies were at a concentration of 3ug/ml. AS-1 rabbit 1

Anti-MTBP [2C1E11] Product

MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 […]

Western blot analysis using H1299 and MCF7 lysates. 7.5% gel; 25ug/well. Antibodies were used at 3ug/ml.

Anti-MTBP [2C1G6] Product

MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 […]