Cat. #152932
Villin-Cre Apcfl/+ KRasG12D/+ Mouse
Cat. #: 152932
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Cancer
Model: Conditional Knock-Out
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Owen Sansom
Institute: Cancer Research UK, Glasgow: The Beatson Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Villin-Cre Apcfl/+ KRasG12D/+ Mouse
- Alternate name: GTPase KRasK-Ras 2Ki-Rasc-K-rasc-Ki-ras
- Cancer: Digestive / Gastrointestinal cancer
- Cancers detailed: Colorectal
- Research fields: Cancer;Genetics
- Tool sub type: Mouse
- Disease: Cancer
- Model: Conditional Knock-Out
- Conditional: Yes
- Description: Oncogenic mutations in the K-ras gene occur in 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: KRasG12D
