ROCK1 Floxed Mouse

ROCK1 is involved in cancer initiation and progression presumably through mechanisms related to metastasis, cell motility and angiogenesis.

Contributors

Inventor Institute
Chris Marshall The Institute of Cancer Research
Cat. #: 153335
Research Fields: Cancer;Cell biology;Developmental biology
Target: Rho Associated Coiled-Coil Containing Protein Kinase 1
Model: Transgenic
Zygosity: Homozygous
Strain: C57BL/6
Alternate name: ROCK1; Rho-associated protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; P16ROCK
Product description: Rho associated coiled-coil containing protein kinases (ROCKs) exist in mammals, zebrafish, Xenopus, C. elegans and Drosophila. They are mainly involved in regulating the shape and movement of cells through acting on the cytoskeleton. Two mouse ROCK isoforms ROCK1 and ROCK2 have been identified. ROCK1 is mainly expressed in the lung, liver, spleen, kidney and testis and ROCK2 is distributed mostly in the brain and heart. ROCK1 and ROCK2 are downstream effectors of the Rho subfamily of small GTPases, activated by Rho GTPases. ROCK2, an isoenzyme of ROCK1, is a serine/threonine kinase and regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibres and activation of the c-fos serum response element. ROCK1 is involved in cancer initiation and progression presumably through mechanisms related to metastasis, cell motility and angiogenesis.
Conditional: Yes
Conditional description: Requires expression of Cre recombinase to mediate excision of the lox P sites generating a non-functional ROCK 1 protein
Genetic background: Lox P sequences were inserted to flank exon 5 of the ROCK 1 gene
Production details: Lox P sequences were inserted to flank exon 5 of the ROCK 1 gene
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Kmper et al. 2016. Elife. 5:e12994. PMID: 26765561.

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.

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