Cat. #151563
K14MycER Mouse
Cat. #: 151563
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Cancer
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: K14MycER Mouse
- Research fields: Cancer;Genetics;Stem cell biology
- Tool sub type: Mouse
- Disease: Cancer
- Conditional: Yes
- Conditional description: Conditional expression of MycER under Keratin 14 promoter giving tissue-specific epidermal expression
- Description: In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)
- Genetic background: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
- Phenotype: Skin abnormalities (hyperproliferation; hair follicle; sebaceous gland);
- Production details: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: cMyc protooncogene (Myc) fused with estragen receptor (ER).
Related Tools
- Related tools: Anti-cMyc [9E10] ; Anti-cMyc [9E11]
