vRRP1 cell line

Drug-resistant sub-lines of A375 that are BRAF^V600E and NRAS WT.

Contributors

Inventor Institute
Christoper Stipp University Of Iowa Research Foundation
Cat. #: 161789
Cancer types: Skin cancer
Research Fields: Cancer;Drug development
Organism: Human
Tissue: Skin
Gender: Female
Morphology: Diffuse Morphology
Primary citation: Zhu et al. 2022. npj Precis. Onc. PMID: 36271142
Alternate name: vRRP1
Product description: Drug-resistant sub-lines of A375 that are BRAF^V600E and NRAS WT. VRPP1 does not harbour NRAS mutations or BRAF genomic alterations, which drive drug resistance through MAPK-reactivation . It Is a VEM-resistant derivatives of A375. VRPP1 is RAC1 WT. Shows Increased VAV1 protein levels. Increased MEK Phosphorylation on S298 (Pak Site).
Gender: Female
Production details: Spontaneous vemurafenib-resistant clones and populations were created after 2–3 and 4–6 weeks cultured in 3 mm vemurafenib. maintained in media with 3 mm vemurafenib.
Parental cell line: A375 Melanoma (ATCC)
Growth medium: DMEM(Gibco) suplemented with penicillin/streptomycin (Gibco) and 10% FBS (Gibco).
References:

Feddersen et al.2019. Cancer Res. 79(19).PMID: 31416844

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