R-3327-3.1 cell line

AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. Following subcutaneous transplantation in syngeneic male rats, AT-3 forms solid sheets of malignant cells with no indication of glandular function.

Contributors

Inventor Institute
John Isaacs Johns Hopkins University
Cat. #: 156407
Unit size: 1×10^6 cells / vial
Cancer types: Prostate cancer
Research Fields: Cancer;Drug development
Model: Cancer Model
Product description: AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. Following subcutaneous transplantation in syngeneic male rats, AT-3 forms solid sheets of malignant cells with no indication of glandular function. AT-3.1 tumors grow continuously with a doubling time of 1.5-1.8 days regardless of the androgen status of the host and exhibit a high rate of metastasis to the lung and lymph nodes (>75% of rats inoculated sub-cutaneously develop distant metastases). The AT-3 subline can be used to study the effects of various types of cancer therapies on prostate cells. Together AT-3 and the related Dunning sublines also provide a valuable model for studying prostate malignancies both in vitro and in vivo.
Cellosaurus ID: CVCL_3570
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.

Ichikawa et al. 1991. Cancer Res. 51(14):3788-92. PMID: 2065333.

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