Cat. #162406
Monoclonal antibody anti-GSK-3 (GSK-4G)
Cat. #: 162406
Sub-type: Primary Antibody
Target: GSK-3 / Shaggy protein kinase family
Class: Monoclonal
Application: WB, IHC, weak in immunoprecipitation
Reactivity: Drosophila, should also cross react with all species homologues. Cross-reacts effectively with rat, Sch. Pombe, Dictyostelium
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
Primary Citation: Harwood et al., Cell (1995) 80 139-148. PMID: 7813009
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Monoclonal antibody anti-GSK-3 (GSK-4G)
- Research fields: Cell signaling and signal transduction
- Clone: 4G-1E
- Tool sub type: Primary Antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Drosophila, should also cross react with all species homologues. Cross-reacts effectively with rat, Sch. Pombe, Dictyostelium
- Host: Mouse
- Application: WB, IHC, weak in immunoprecipitation
- Description: Antibody to glycogen synthase kinase 3, a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer. The peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Because of the extremely high conservation of this region among the known enzymes of many different species clone 4G-1E, which recognizes the Drosophila enzyme, should cross react with all species homologues (cross-reacts effectively with rat, Sch. Pombe, Dictyostelium*).
- Immunogen: Synthetic peptide coupled to ovalbumin : (C)K203 QLLHGEPNVSYICSRY219
- Isotype: IgG1, K
- Additional notes: Avoid repeat freezing and thawing cycles. Does not contain any preservative.
Target Details
- Target: GSK-3 / Shaggy protein kinase family
- Target background: Glycogen synthase kinase 3 is a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer.
Applications
- Application: WB, IHC, weak in immunoprecipitation
- Application notes: Available as Crude Ascites Fluid. Recommended dilutions 1/1000-1/5000
Handling
- Storage conditions: -20°C (up to 3 years)
References
- Harwood et al., Cell (1995) 80 139-148, PMID: 7813009
