Anti-XRCC3 [XRCC3 10F1/6] mAb

X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is […]

Contributors

Inventor Institute
Stephen West Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151256
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics;Microbiology
Application: IHC ; WB
Target: XRCC3
Reactivity: Human
Clone: XRCC3 10F1/6
Host: Mouse
Class: Monoclonal
Product description: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 37.8 kDa
Immunogen: His-tagged human XRCC3
Myeloma used: Sp2/0-Ag14
Target background: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
Format: Liquid
Concentration: 0.94 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Agostini et al. 2015. Cancer Biol Ther. 16(8):1160-71. PMID: 26023803.

Li et al. 2014. Sci Signal. 7(326):ra47. PMID: 24847116.

Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.

Identification and purification of two distinct complexes containing the five RAD51 paralogs.

Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.

Complex formation by the human RAD51C and XRCC3 recombination repair proteins.

Tebbs et al. 1995. Proc Natl Acad Sci U S A. 92(14):6354-8. PMID: 7603995.

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

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