This antibody is useful for the detection of WIPI-2, an essential protein for autophagy.
| Inventor | Institute |
|---|---|
| Sharon Tooze | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151651 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Cancer;Tissue-specific biology |
| Application: | IF ; FACS ; IF ; IP ; WB |
| Target: | WIPI2 |
| Reactivity: | Human ; Mouse |
| Clone: | 2A2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | This antibody is useful for the detection of WIPI-2, an essential protein for autophagy. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 49 kDa |
| Immunogen: | Synthetic peptide corresponding to C-terminus of WIPI2b CSALRLDEDSEHPPMILRTD |
| Target background: | WIPI2 is a mammalian effector of PtdIns3P and is ubiquitously expressed in a variety of cell lines. WIPI2 is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. WIPI-2 is the mammalian homologue of Atg18. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Nishimura et al. 2017. EMBO J. 36(12):1719-1735. PMID: 28495679. Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains. Martinez-Martin et al. 2017. Science. 355(6325):641-647. PMID: 28183981. A switch from canonical to noncanonical autophagy shapes B cell responses. Polson et al. 2010. Autophagy. 6(4):506-22. PMID: 20505359. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Li et al. 2005. J Biol Chem. 280(29):26941-52. PMID: 15917248. Krppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. Benzeno et al. 2004. Cancer Res. 64(11):3885-91. PMID: 15172998. Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. |
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