Cat. #151339
Anti-SIGLEC2 [4KB128]
Cat. #: 151339
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Sialic acid binding Ig-like lectin 2 (SIGLEC2, CD22, BL-CAM)
Class: Monoclonal
Application: FACS
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Karen Pulford
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-SIGLEC2 [4KB128]
- Research fields: Cancer;Immunology;Stem cell biology
- Clone: 4KB128
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS
- Description: SIGLEC-2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias.
- Immunogen: B cell lymphoma cells
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Sialic acid binding Ig-like lectin 2 (SIGLEC2, CD22, BL-CAM)
- Target background: SIGLEC-2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias.
Applications
- Application: FACS
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Law et al. 1994. Immunol Today. 15(9):442-9. PMID: 7945784.
- Regulation of lymphocyte activation by the cell-surface molecule CD22.
- Mason et al. 1987. Blood. 69(3):836-40. PMID: 3101766.
- Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.
- Campana et al. 1985. J Immunol. 134(3):1524-30. PMID: 3918103.
- Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue.
