Anti-phospho Sam68, Ser113/117

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-phospho Sam68, Ser113/117
• Alternate name: KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68
• Cancer type: Ovarian cancer
• Cancers detailed: Ovarian
• Research fields: Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Genetics
• Tool sub type: Primary antibody
• Class: Polyclonal
• Purpose: Marker
• Conjugation: Unconjugated
• Molecular weight: 68 kDa
• Reactivity: Human ; Mouse ; Rat
• Host: Rabbit
• Application: IHC ; WB
• Description: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-Î?B) compl...
• Immunogen: Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH)

Target Details

• Target: Sam68(Src-associatedduringmitosis,68 kDa)
• Molecular weight: 68 kDa
• Tissue cell line specificity: Rabbit
• Target background: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-B) co...

Applications

• Application: IHC ; WB

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Dry ice

References

• Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.
• Sam68 modulates the promoter specificity of NF-B and mediates expression of CD25 in activated T cells.