Anti-PDL2 (soluble form) [Z64P2D3*H4] mAb

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-PDL2 (soluble form) [Z64P2D3*H4] mAb
• Alternate name: B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC14224, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2
• Research fields: Immunology
• Clone: Z64P2D3*H4
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; IHC ; WB
• Description: Monoclonal antibody which can aid understanding of programmed death ligand 2, in the secreted form. Background and Research Application PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.). PDL2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
• Immunogen: Ovalbumin-conjugated synthetic peptide KAVFFKRHN
• Immunogen uniprot id: Q9BQ51
• Isotype: IgG2b kappa
• Myeloma used: P3X63Ag8.653
• Recommended controls: IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray

Target Details

• Target: Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form)
• Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray
• Target background: Monoclonal antibody which can aid understanding of programmed death ligand 2, in the secreted form. Background and Research Application PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.). PDL2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.

Applications

• Application: ELISA ; IHC ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
• Shipping conditions: Shipping at 4° C

Related Tools

• Related tools: Anti-PDL2 (soluble form), Recombinant [Z64P2D3*H4]