Cat. #151841
Anti-NSun2 [EF-1]
Cat. #: 151841
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: NSun2 (Misu)
Class: Polyclonal
Application: IF ; IP ; WB
Reactivity: Human
Host: Rabbit
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Michaela Frye ; Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-NSun2 [EF-1]
- Cancer: Breast cancer
- Cancers detailed: Breast cancer
- Research fields: Genetics
- Clone: EF-1
- Tool sub type: Primary antibody
- Class: Polyclonal
- Conjugation: Unconjugated
- Molecular weight: 80 kDa
- Reactivity: Human
- Host: Rabbit
- Application: IF ; IP ; WB
- Description: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
- Immunogen: NSun2 (Misu) peptides conjugated with keyhole limpet hemocyanin
- Immunogen uniprot id: N/A
- Recommended controls: Human keratinocytes, human breast cancer cell lines
Target Details
- Target: NSun2 (Misu)
- Molecular weight: 80 kDa
- Tissue cell line specificity: Human keratinocytes, human breast cancer cell lines
- Target background: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
Applications
- Application: IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: Whole serum
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597.
- Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.
- Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847.
- The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.
- Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953.
- The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
