#153394

Anti-Lewis Y [C14]

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Cat. #153394

Anti-Lewis Y [C14]

Cat. #: 153394

Sub-type: Primary antibody

Unit size: 100 ug

Target: Lewis Y

Class: Monoclonal

Application: ELISA ; FACS ; IHC

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Mike Price

Institute: University of Nottingham

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Lewis Y [C14]
  • Research fields: Cancer;Genetics
  • Clone: C14
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC
  • Description: MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are functional glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.
  • Immunogen: Tumor cells
  • Isotype: IgG

Target Details

  • Target: Lewis Y
  • Target background: MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are Fn glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.

Applications

  • Application: ELISA ; FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Durrant et al. 1989. J Natl Cancer Inst. 81(9):688-96. PMID: 2468779.
  • Flow cytometric screening of monoclonal antibodies for drug or toxin targeting to human cancer.