Cat. #153393
Anti-Lewis Y [69/229]
Cat. #: 153393
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Lewis Y
Class: Monoclonal
Application: FACS ; IHC
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Lindy Durrant
Institute: University of Nottingham
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Lewis Y [69/229]
- Research fields: Cancer;Genetics
- Clone: 69/229
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC
- Description: MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are functional glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.
- Immunogen: Colonic Adenoma membranes
- Isotype: IgG3 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Lewis Y
- Target background: MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are Fn glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.
Applications
- Application: FACS ; IHC
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Noble et al. 2013. PLoS One. 8(2):e54892. PMID: 23408949.
- Therapeutic targeting of Lewis(y) and Lewis(b) with a novel monoclonal antibody 692/29.
