UCH-T4 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc.
| Inventor | Institute |
|---|---|
| Peter Beverley | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151177 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology;Stem cell biology |
| Application: | FACS ; IHC ; IF |
| Target: | Leu2 (CD8) |
| Reactivity: | Human |
| Clone: | UCH-T4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232. |
| Product description: | UCH-T4 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 32 kDa |
| Immunogen: | Thymocytes followed by Sezary T cells. |
| Target background: | Leu-2 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. Leu-2 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232 Waleh et al. 2011. Pediatr Res. 70(4):332-8. PMID: 21691249. Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation. Martn et al. 2002. J Cutan Pathol. 29(6):347-53. PMID: 12135465. Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis. Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569. beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum. |
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