LHK6 is a very good marker for hyperproliferative keratinocytes.
| Inventor | Institute |
|---|---|
| Nick Tidman | Queen Mary University of London |
| Cat. #: | 151440 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | ELISA ; FACS ; IHC ; IF ; WB |
| Target: | Keratin 6 |
| Reactivity: | Human ; Mouse |
| Clone: | LHK6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6EHuman Entrez Gene ID 3853-KRT6A, 3854-KRT6B, 286887-KRT6C Human SwissProt P2538-KRT6A, P4259-KRT6B, P48668-KRT6C Human Unigene 7779 Human Gene Symbol KRT6A; KRT6B; KRT6CHuman Chromosome Location 12q13.13; 12q13.13; 12q13.13 |
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| Product description: | LHK6 is a very good marker for hyperproliferative keratinocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Molecular weight: | 55-57 kDa |
| Immunogen: | 11 amino aid sequence GSSTIKYTTTS of K6b C terminal |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Clone LHK6 recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratin 9 to 23) and on type II kerating (1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 6,16 and 17 are expressed in suprabasasl keratinocytes of wounded epidermis. Keratin 6 is found in acrosyringeal keratinocyes in normal skin. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Toivola et al. 2002. Mol Biol Cell. 13(6):1857-70. PMID: 12058054. Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells. Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530. K15 expression implies lateral differentiation within stratified epithelial basal cells. Machesney et al. 1998. Am J Pathol. 152(5):1133-41. PMID: 9588880. Activated keratinocytes in the epidermis of hypertrophic scars. Wetzels et al. 1991. Am J Pathol. 138(3):751-63. PMID: 1705754. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. |
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