a6 chain showed positive staining of the basement membrane domain of basal cells and either weak positive or negative staining of the luminal epithelial cells (Fig. 3). (ANBAZHAGAN et al. JOURNAL OF PATHOLOGY; VOL. 176 227-232 (1995))

Cat. #151134

Anti-Integrin alpha 6 [MP4F10]

Name: Anti-Integrin alpha 6 [MP4F10]
SKU: 151134
Availability: InStock

Cat. #: 151134

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Integrin alpha6 (CD49f)

Class: Monoclonal

Application: IF ; ICC ; FACS ; IHC ; IP ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

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Contributor

Inventor: Walter Bodmer

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Primary Citation: Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.

Tool Details

Target Details

Applications

Handling

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Name: Anti-Integrin alpha 6 [MP4F10]
Research fields: Cell biology;Developmental biology;Stem cell biology
Clone: MP4F10
Tool sub type: Primary antibody
Class: Monoclonal
Conjugation: Unconjugated
Molecular weight: 118/100
Strain: Balb/c
Reactivity: Human
Host: Mouse
Application: IF ; ICC ; FACS ; IHC ; IP ; WB
Description: MP 4F10 may be used in clinical studies for tumour grading as it will stain both moderately and well-differentiated colorectal adenocarcinoma.
Immunogen: SW1222 human colorectal cell line.
Isotype: IgG1 kappa
Myeloma used: P3/NS1/1-Ag4.1

Target Details

Target: Integrin alpha6 (CD49f)
Molecular weight: 118/100
Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin alpha 6 associates with integrin beta 4 to form integrin a6b4, one of the most abundant keratinocyte integrins, and binds laminin.

Applications

Application: IF ; ICC ; FACS ; IHC ; IP ; WB

Handling

Format: Liquid
Concentration: 1 mg/ml
Unit size: 100 ug
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

References

Zhou et al. 2019. Stem Cell Res Ther. 10(1):155. PMID: 31151466.
Pieri et al. 2019. Stem Cell Res Ther. 10(1):135. PMID: 31109365.
Kapsokalyvas et al. 2017. Colloids Surf B Biointerfaces. 159:97-107. PMID: 28780465.
Zhang et al. 2017. PLoS One. 12(2):e0172207. PMID: 28234938.
Zhang et al. 2016. Cell Reprogram. 18(6):401-410. PMID: 27906584.
Al Thawadi et al. 2016. Oncotarget. 7(5):5289-305. PMID: 26700621.
Stempin et al. 2015. Cancer Cell Int. 15:110. PMID: 26612978.
Svensson Mnsson et al. 2007. J Pathol. 212(1):102-11. PMID: 17370299.
Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.
Anbazhagan et al. 1995. J Pathol. 176(3):227-32. PMID: 7674085.
Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.