Anti-IgM [UCH-B1]

Antibody UCHB1 recognizes surface expressed and soluble human IgM.

Contributors

Inventor Institute
Peter Beverley Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 152696
Tool sub type: Secondary antibody
Unit size: 100 ug
Research Fields: Immunology;Stem cell biology
Application: IP ; FACS ; IHC ; IF ; Fn
Target: Prolymphocytic leukaemia B cells Leukemia
Reactivity: Human
Clone: UCH-B1
Host: Mouse
Class: Monoclonal
Alternate name: B-lymphocytes, IgM, B cell antigen receptor (BCR)
Product description: Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for functional BCR complex assembly. Antibody UCHB1 recognizes surface expressed and soluble human IgM.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 85 kDa
Immunogen: Human prolymphocytic leukaemia B cells.
Myeloma used: NS0
Target background: Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for Fn BCR complex assembly. Antibody UCHB1 recognizes surface expressed and soluble human IgM.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Grupp et al. 1995. J Exp Med. 181(1):161-8. PMID: 7807000.

Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.

DeFranco et al. 1994. Chem Immunol. 59:156-72. PMID: 7945925.

Structure and function of the B-cell antigen receptor.

Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1):181-7. PMID: 2208792.

Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells.

Armitage et al. 1988. Eur J Immunol. 18(1):67-76. PMID: 3257923.

A new antigen identified by the monoclonal antibody UCHB 1 delivers a costimulatory signal to a subset of human B cells.

Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.

Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.

Images

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Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1)

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