Anti-HLADR [CR3/43]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-HLADR [CR3/43]
• Research fields: Immunology
• Clone: CR3/43
• Tool sub type: Primary antibody
• Class: Monoclonal
• Purpose: Marker
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC ; WB
• Description: Monoclonal antibody capable of HLA typing, reacting with subregions of class II antigens.
• Immunogen: Tonsil cells
• Immunogen uniprot id: P01903
• Isotype: IgG1
• Myeloma used: P3/NS1/1-Ag4.1

Target Details

• Target: Human Leukocyte Antigen DR (MHC class II)
• Tissue cell line specificity: Mouse
• Target background: Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. ...

Applications

• Application: FACS ; IHC ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
• Shipping conditions: Dry ice

References

• Baiardi et al. 2019. Ann Clin Transl Neurol. 6(2):263-273. PMID: 30847359.
• Kalsow et al. 2017. Ocul Immunol Inflamm. 25(6):878-883. PMID: 27715362.
• Kagami et al. 2017. J Clin Exp Hematop. 57(1):9-14. PMID: 28420813.
• van Duijn et al. 2017. J Alzheimers Dis. 60(4):1533-1545. PMID: 29081415.
• Breshears et al. 2012. J Biol Chem. 287(39):32578-87. PMID: 22833676.
• A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial resp...