#160586

Anti-hEMILIN1 [hEMIL1]

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Cat. #160586

Anti-hEMILIN1 [hEMIL1]

Cat. #: 160586

Sub-type: Primary antibody

Unit size: 100 ug

Target: hEMILIN1

Class: Monoclonal

Application: ELISA ; IHC ; IF ; IP ; Fn ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Alfonso Colombatti ; Maurizio Mongiat ; Paola Spessotto ; Roberto Doliana ; Maria Teresa Mucignat

Institute: National Cancer Institute CRO - Aviano

Tool Details
Target Details
Applications
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-hEMILIN1 [hEMIL1]
  • Research fields: Cell biology;Cell signaling and signal transduction
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF ; IP ; Fn ; WB
  • Description: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the Î?4Î?1 integrin via the C-terminal gC1q domain exerts a negative effect on proliferation. It binds pro-TGFÎ? preventing its maturation to mature TGFÎ? in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
  • Immunogen: Recombinant human Emilin-1 as immunizing antigen; Balb/c mice as host
  • Recommended controls: IgG2a kappa

Target Details

  • Target: hEMILIN1
  • Tissue cell line specificity: IgG2a kappa
  • Target background: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the a4?1 integrin via...

Applications

  • Application: ELISA ; IHC ; IF ; IP ; Fn ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage conditions: Store at 2 - 8° C or aliquots at -20° C. Avoid repeated freeze-thaw cycles
  • Shipping conditions: Shipping at 4° C

Related Tools

  • Related tools: Anti-hEMILIN2 [hEMIL2] monoclonal antibody ; Anti-mMMRN2 [mMMRN2] monoclonal antibody ; Anti-mEMILIN1 [mEMIL] monoclonal antibody

References

  • Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.
  • Pivetta et al. 2014. Matrix Biol. 34:22-32. PMID: 24513040.
  • Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.
  • Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.
  • Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.
  • Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.
  • Spessotto et al. 2006. J Cell Sci. 119(Pt 21):4574-84. PMID: 17074837.
  • Zacchigna et a...