The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.
| Inventor | Institute |
|---|---|
| Gerard Evan | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152697 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Cervical cancer, Colorectal cancer, Breast cancer, Lung cancer |
| Research Fields: | Cancer;Cell biology;Genetics;Stem cell biology |
| Application: | IHC ; IP ; WB |
| Target: | cMyc, c-Myc |
| Reactivity: | Human |
| Clone: | PM3E7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | A synthetic peptide APSEDIWKKFEL corresponding to amino acids 44-55 of c-Myc coupled to PPD |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Evan et al. 1988. Curr Top Microbiol Immunol. 141:189-201. PMID: 3063442. Immunological probes in the analysis of myc protein expression. |
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