Monoclonal antibody used to study the expression pattern of CLEC-2 receptor.
| Inventor | Institute |
|---|---|
| Caetano Reis e Sousa | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151581 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology;Tissue-specific biology |
| Application: | FACS ; WB |
| Target: | Ctype lectin-like receptor (CLEC2) |
| Reactivity: | Mouse |
| Clone: | 17D9 |
| Host: | Rat |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody used to study the expression pattern of CLEC-2 receptor. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Immunogen: | RBL-2H3 cells stably expressing HA-tagged mouse CLEC-2 |
| Immunogen Uniprot ID: | Q9P126 |
| Myeloma used: | Y3.AG.1.2.3 |
| Target background: | CLEC-2 belongs to a sub-family of C-type lectin receptors that signal through Syk via a single YxxL motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower level on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. CLEC-2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC-2 also functions as an activation receptor on monocytes and neutrophils to induce phagocytosis and proinflammatory cytokine production. This antibody can be used as a selective agonist of CLEC-2 and also to study its expression pattern. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Kerrigan et al. 2009. J Immunol. 182(7):4150-7. PMID: 19299712. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. |
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