Anti-CD4 V1 domain [QS4120]

Cat. #151155

Anti-CD4 V1 domain [QS4120]

Cat. #: 151155

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: CD4 V1 domain

Class: Monoclonal

Application: ELISA ; FACS ; IF ; Fn

Reactivity: Human

Host: Mouse


This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.


Inventor: Peter Beverley

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-CD4 V1 domain [QS4120]
  • Alternate name: CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Receptor; CD4 Antigen
  • Research fields: Immunology;Stem cell biology
  • Clone: QS4120
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IF ; Fn
  • Description: Anti-CD4 V1 domain [QS4120] binds to domain 1 of CD4 and blocks binding of gp120 to CD4 (Ringe and Bhattacharya, 2012).
  • Immunogen: CD4+ transfectant followed by CEM cells
  • Isotype: IgG1
  • Myeloma used: P3/NS1/1-Ag4.1
  • Recommended controls: Human colonic mucus, epithelial cells and cell membranes.

Target Details

  • Target: CD4 V1 domain
  • Tissue cell line specificity: Human colonic mucus, epithelial cells and cell membranes.
  • Target background: CD4 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class II molecules. CD4 cell counts are used as indicator of AIDS progression. In addition to virus binding, CD4 may have an active role in membrane fusion.


  • Application: ELISA ; FACS ; IF ; Fn


  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C


  • Helling et al. 2015. Immunol Cell Biol. 93(4):396-405. PMID: 25512343.
  • A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.
  • Ringe et al. 2012. PLoS One. 7(5):e37157. PMID: 22606344.
  • Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity.
  • Sadovnikova et al. 2002. Leukemia. 16(10):2019-26. PMID: 12357353.
  • The CD68 protein as a potential target for leukaemia-reactive CTL.
  • Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532.
  • Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.
  • Ugolini et al. 1997. J Immunol. 159(6):3000-8. PMID: 9300725.
  • HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.
  • Healey et al. 1990. J Exp Med. 172(4):1233-42. PMID: 1698911.
  • Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.
  • McClure et al. 1987. Nature. 330(6147):487-9. PMID: 2446142.
  • HIV infection of primate lymphocytes and conservation of the CD4 receptor.