Anti-CD4 V1 domain [QS4120] binds to domain 1 of CD4 and blocks binding of gp120 to CD4 (Ringe and Bhattacharya, 2012).
| Inventor | Institute |
|---|---|
| Peter Beverley | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151155 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology;Stem cell biology |
| Application: | ELISA ; FACS ; IF ; Fn |
| Target: | CD4 V1 domain |
| Reactivity: | Human |
| Clone: | QS4120 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Receptor; CD4 Antigen |
|---|---|
| Product description: | Anti-CD4 V1 domain [QS4120] binds to domain 1 of CD4 and blocks binding of gp120 to CD4 (Ringe and Bhattacharya, 2012). |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | CD4+ transfectant followed by CEM cells |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CD4 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class II molecules. CD4 cell counts are used as indicator of AIDS progression. In addition to virus binding, CD4 may have an active role in membrane fusion. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Helling et al. 2015. Immunol Cell Biol. 93(4):396-405. PMID: 25512343. A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Ringe et al. 2012. PLoS One. 7(5):e37157. PMID: 22606344. Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity. Sadovnikova et al. 2002. Leukemia. 16(10):2019-26. PMID: 12357353. The CD68 protein as a potential target for leukaemia-reactive CTL. Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532. Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction. Ugolini et al. 1997. J Immunol. 159(6):3000-8. PMID: 9300725. HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4. Healey et al. 1990. J Exp Med. 172(4):1233-42. PMID: 1698911. Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding. McClure et al. 1987. Nature. 330(6147):487-9. PMID: 2446142. HIV infection of primate lymphocytes and conservation of the CD4 receptor. |
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