C-APC 28.8 can be used for APC expression and detection of APC mutations.
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152092 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Digestive / Gastrointestinal cancer |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Genetics;Neurobiology;Stem cell biology;Tissue-specific biology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | APC |
| Reactivity: | Human |
| Clone: | c-APC 28.9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | C-APC 28.8 can be used for APC expression and detection of APC mutations. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 320 kDa |
| Immunogen: | human APC C-terminal fusion with MBP (maltose binding protein) |
| Target background: | The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. Clone c-APC 28.9 is useful for the detection of APC expression and detection of mutations. This antibody has been used routinely for Western blotting on colon cell line HCT116 extract which expresses full-length APC. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Kariola et al. 2005. Fam Cancer. 4(2):187-90. PMID: 15951972. APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. Fodde et al. 2001. Nat Cell Biol. 3(4):433-8. PMID: 11283620. Mutations in the APC tumour suppressor gene cause chromosomal instability. |
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