Monoclonal antibody which can aid detection of ovarian and testicular cancers.
| Inventor | Institute |
|---|---|
| Peter Beverley | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151885 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | IHC |
| Target: | Calf alkaline phosphatase |
| Reactivity: | Bovine ; Human |
| Clone: | AP1B9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which can aid detection of ovarian and testicular cancers. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Calf Alkaline phosphatase |
| Immunogen Uniprot ID: | P09923 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Hoene et al. 2020. J Biomed Mater Res A. 108(4):871-881. PMID: 31846170. Lucke et al. 2018. J Biomed Mater Res A. 106(10):2726-2734. PMID: 30051967. Lucke et al. 2015. Biomed Res Int. 2015:938059. PMID: 25648958. Erlach et al. 2002. J Virol. 76(6):2857-70. PMID: 11861853. Tumor control in a model of bone marrow transplantation and acute liver-infiltrating B-cell lymphoma: an unpredicted novel function of cytomegalovirus. |
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