#152533

Anti-ADAM17 [17MOCYT]

Cat. #152533

Anti-ADAM17 [17MOCYT]

Cat. #: 152533

Sub-type: Primary antibody

Unit size: 100 ug

Target: ADAM17

Class: Polyclonal

Application: WB

Reactivity: Mouse

Host: Rabbit

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Carl Blobel

Institute: Hospital for Special Surgery

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-ADAM17 [17MOCYT]
  • Research fields: Cancer;Cell signaling and signal transduction;Metabolism;Neurobiology;Stem cell biology
  • Clone: 17MOCYT
  • Tool sub type: Primary antibody
  • Class: Polyclonal
  • Conjugation: Unconjugated
  • Molecular weight: ~100 kDa (mature form), ~120 kDa (pro-form)
  • Reactivity: Mouse
  • Host: Rabbit
  • Application: WB
  • Description: ADAM17 (TACE/CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis.
  • Immunogen: GST-cyto corresponding to the cytoplasmic domain of murine ADAM17

Target Details

  • Target: ADAM17
  • Molecular weight: ~100 kDa (mature form), ~120 kDa (pro-form)
  • Target background: ADAM17 (TACE/CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis.

Applications

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: Whole serum
  • Storage conditions: -20° C
  • Shipping conditions: Shipping at 4° C

References

  • Horiuchi et al. 2007. J Immunol. 179(5):2686-9. PMID: 17709479.
  • Le Gall et al. 2010. J Cell Sci. 123(Pt 22):3913-22. PMID: 20980382.
  • Maretzky et al. 2011. Nat Commun. 2:229. PMID: 21407195.
  • Schlndorff et al. 2000. Biochem J. 347 Pt 1:131-8. PMID: 10727411.
  • Zheng et al. 2002. J Biol Chem. 277(45):42463-70. PMID: 12207026.