Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.
| Inventor | Institute |
|---|---|
| David Becker | University College London (UCL) |
| Cat. #: | 151523 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Neurobiology |
| Application: | IHC ; IF ; WB |
| Target: | Connexin 43 (Cx43 or a1) |
| Reactivity: | Mouse |
| Clone: | 1A |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Immunogen: | The peptide, EIKKFKYGIEEH, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 4060:1. |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Gorbe et al. 2007. Exp Cell Res. 313(6):1135-48. PMID: 17331498. Myoblast proliferation and syncytial fusion both depend on connexin43 function in transfected skeletal muscle primary cultures. Pearson et al. 2005. J Neurosci. 25(46):10803-14. PMID: 16291954. Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells. Saitongdee et al. 2004. J Histochem Cytochem. 52(5):603-15. PMID: 15100238. Levels of gap junction proteins in coronary arterioles and aorta of ha… |
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