Cat. #154474

Glycated HSA Rhodamine Boronic Acid small molecule (tool compound)

Cat. #: 154474

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This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

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Contributor

Inventor: Marta P. Pereira Morais

Institute: University of Bath

Tool Details

Handling

Target Details

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Tool name: Glycated HSA Rhodamine Boronic Acid small molecule (tool compound)
Alternate name: AGEs
Research fields: Cancer;Cell biology
Primary target: Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein.
Description: Protein glycation, also known as non-enzymatic glycosylation, has been implicated in various disease states and is therefore an important biomarker for ageing and age-related chronic diseases such as diabetes, cardiovascular diseases, autoimmune diseases, cancer, and Alzheimer's disease. However their analysis is challenging due to the complexity of the protein-carbohydrate adducts. Fluorescent boronic acids like these enable the detection and identification of individual glycated proteins in...
Additional notes: This small molecule has been used to identify glycated proteins in human serum, insect hemolymph, and mouse brain homogenates.

Handling

Shipping conditions: Dry Ice

Target Details

Primary target: Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein.

References

Pereira Morais et al. 2013. Sci Rep. 3:1437. PMID: 23531746.