Cat. #160405
Glucose-6-phosphate Dehydrogenase inhibitor G6PD Small Molecule (Tool Compound)
Cat. #: 160405
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ian Waddell
Institute: Cancer Research UK Manchester Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Glucose-6-phosphate Dehydrogenase inhibitor G6PD Small Molecule (Tool Compound)
- Alternate name: G6PD; G6PD1; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase; glucose-6-phosphate dehydrogenase, glucose 6 phosphate dehydrogenase
- Cancer: Head and neck cancer
- Cancers detailed: Gastric;Larynx
- Research fields: Cancer;Cell signaling and signal transduction;Drug development
- Tool sub type: Inhibitor
- Description: A selective inhibitor of Glucose-6-phosphate dehydrogenase (G6PD) which demonstrates anti-cancer activity. G6PD is a critical metabolic enzyme involved in the oxidative phase of the pentose phosphate pathway. Chinese hamster ovary cells that are devoid of G6PD display increased sensitivity to radiation and human fibroblasts deficient in G6PD display increased ROS and radiation sensitivity. Clinically, evidence from studies in larynx and gastric cancer suggests that tumours show increased G6PD activity, and this correlates to a poor clinical outcome.
- Purpose: Inhibitor
- Selectivity: Inhibitory activity against related targets as % inhibition at given concentration: 6PGDH: 4.7% at 200 ÂľM IDH: 0.9% at 200 ÂľM RET: 4.8% at 100 ÂľM LSD1: 6.3% at 40 ÂľM
- Solubility: 30-100M in PBS
- Additional notes: Relevant Indications: Larynx cancer, Gastric cancer
Handling
- Shipping conditions: Dry Ice
Target Details
- Ic50: 1.0 uM
References
- Hamilton et al. 2012. J Med Chem. 55(9):4431-45. PMID: 22506561.
- Hitchin et al. 2012. Tetrahedron Letters. 53:2868-72
