Cat. #153508
Paraneoplastic Hu Antigen, Recombinant Protein [5]
Cat. #: 153508
Availability: Please enquire for quantities and pricing
Target: HuD
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Clonegene LLC
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Paraneoplastic Hu Antigen, Recombinant Protein [5]
- Research fields: Cancer;Developmental biology;Genetics;Neurobiology
- Cellular tissue localisation: Expressed in neurons and a paraneoplastic antigen expressed in neuroendocrine tumours
- Source: E.coli
- Target: HuD
- Description: HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy.
- Tag: MBP fusion protein
- Expression system: Recombinant
- Additional notes: Expressed in E.coli as a 6his and MBP fusion protein and purified by MBP-tag affinity chromatography
Handling
- Storage conditions: Store at 4° C; long term storage at -20° C
- Shipping conditions: Dry Ice
Target Details
- Target: HuD
Application Details
- Application notes: Expressed in E.coli as a 6his and MBP fusion protein and purified by MBP-tag affinity chromatography
