NF704 peptide

Use of cell-penetration peptides can increase the transport efficiency of extracellular synthetic nucleic acids, such as siRNAs, to help increase concentration of the siRNA at the desired cellular location.

Contributors

Inventor Institute
Piret Arukuusk ; Ly Porosk ; Ülo Langel University of Tartu
Cat. #: 157650
Tool sub type: Synthetic Peptide
Research Fields: Genetics
Alternate name: NickFect74
Product description: This peptide can be used to transport siRNA into cells. Use of cell-penetration peptides can increase the transport efficiency of extracellular synthetic nucleic acids, such as siRNAs, to help increase concentration of the siRNA at the desired cellular location. This peptide is based on NickFect55 (NF55) which is a peptide that can efficiently transport plasmid DNA into cells in vivo. To improve the efficiency of nucleic acid delivery, this peptide has been developed to improve the intracellular release mechanism resulting in higher local dosage of the cargo.
Additional notes: There is a stearoyl (18-carbon) fatty acid chain attached to the N-terminus of the peptide. The sequence in brackets is attached to the sidechain amino group rather than the a-amino group.
Function: siRNA delivery
Tag: stearoyl (18-carbon) fatty acid chain attached to the N-terminus of the peptide
Expression system: Synthetic
References:

Porosk et al. 2019. Biomater Sci. 7(10):4363-4374. PMID: 31411219.

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