Cat. #152932

Villin-Cre Apcfl/+ KRasG12D/+ Mouse

Cat. #: 152932

Sub-type: Mouse

Availability: 8-10 weeks

Disease: Cancer

Model: Conditional Knock-Out

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Contributor

Inventor: Owen Sansom

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

Handling

Target Details

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Tool name: Villin-Cre Apcfl/+ KRasG12D/+ Mouse
Alternate name: GTPase KRasK-Ras 2Ki-Rasc-K-rasc-Ki-ras
Cancer type: Colorectal cancer
Cancers detailed: Colorectal
Research fields: Cancer;Genetics
Tool sub type: Mouse
Disease: Cancer
Model: Conditional Knock-Out
Conditional: Yes
Description: Oncogenic mutations in the K-ras gene occur in 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.

Handling

Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

Target: KRasG12D