Villin-Cre Apcfl/+ KRasG12D/+ Mouse

conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.

Contributors

Inventor Institute
Owen Sansom Cancer Research UK, Glasgow: The Beatson Institute
Cat. #: 152932
Cancer types: Colorectal cancer
Research Fields: Cancer;Genetics
Target: KRasG12D
Disease: Cancer
Model: Conditional Knock-Out
Alternate name: GTPase KRasK-Ras 2Ki-Rasc-K-rasc-Ki-ras
Product description: Oncogenic mutations in the K-ras gene occur in 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.
Conditional: Yes
Shipping conditions: Embryo/Spermatoza- Dry Ice

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