#152932

Villin-Cre Apcfl/+ KRasG12D/+ Mouse

Cat. #152932

Villin-Cre Apcfl/+ KRasG12D/+ Mouse

Cat. #: 152932

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Cancer

Model: Conditional Knock-Out

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Contributor

Inventor: Owen Sansom

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details
Handling
Target Details

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Villin-Cre Apcfl/+ KRasG12D/+ Mouse
  • Alternate name: GTPase KRasK-Ras 2Ki-Rasc-K-rasc-Ki-ras
  • Cancer: Digestive/Gastrointestinal cancer
  • Cancers detailed: Colorectal
  • Research fields: Cancer;Genetics
  • Tool sub type: Mouse
  • Disease: Cancer
  • Model: Conditional Knock-Out
  • Conditional: Yes
  • Description: Oncogenic mutations in the K-ras gene occur in 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: KRasG12D