Cat. #158393
p110beta PI3K-DEL21/22 (B6)
Cat. #: 158393
Sub-type: Mouse
Availability: 8-10 weeks
Model: Knock-Out
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Bart Vanhaesebroeck
Institute: Ludwig Institute for Cancer Research ; The University of Edinburgh
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: p110beta PI3K-DEL21/22 (B6)
- Research fields: Cancer
- Tool sub type: Mouse
- Model: Knock-Out
- Genetic background: Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
- Phenotype: Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.
- Production details: Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
- Additional notes: Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: PIK3CB
References
- Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
- Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.
