MAGL-Flox mouse

Useful model for the generation of tissue/cell specific MAGL-deficient mice

Contributors

Inventor Institute
Robert Zimmermann ; Franz Radner University of Graz
Cat. #: 160870
Research Fields: Cell signaling and signal transduction;Metabolism
Target: Monoglyceride lipase; monoacyl glycerol lipase
Model: Conditional KO
Zygosity: Homozygous
Strain: C57BL/6J
Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
Alternate name: MGL, Mgll, Magl
Product description: Useful model for the generation of tissue/cell specific MAGL-deficient mice. Animals might be useful for studies, e.g. on energy metabolism or endocannabinoid signalling.
Conditional: Yes
Conditional description: Targeted, conditional ready
Production details: A floxed neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette leaving Mgll exon 3 and 4 floxed. Further details are available upon request.
References:

21454566

26565024

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