Cat. #151551
Inva2b1 Mouse
Cat. #: 151551
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Psoriasis
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Inva2b1 Mouse
- Research fields: Cell biology;Genetics
- Tool sub type: Mouse
- Disease: Psoriasis
- Conditional: Yes
- Conditional description: Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
- Description: Disease model for psoriasis; in vivo study of human alpha2 and beta1 integrin transgene expression in skin.
- Genetic background: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
- Phenotype: Skin abnormalities (abnormal keratinocyte differentiation, hyperproliferation, inflammatory lesions)
- Zygosity: Heterozygous
- Production details: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
- Additional notes: Mice present phenotype very similar to human psoriasis disease.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Alpha2 intergrin, beta1 integrin
References
- Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
- Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
