VCaP 10 [FLU G] CRPC Cell line

vCaP FLU was created through ADT and flutamide to be used as a model for CRPC

Contributors

Inventor Institute
Wytske van Weerden Erasmus University Medical Centre
Cat. #: 161959
Research Fields: Cancer
Organism: Human
Tissue: Prostate
Model: Tumour Cell Line
Primary citation: Moll JM et al. 2022. Front. Oncol. Jun 13,12:877613. PMID: 35769712
Product description: CRPC VCaP cell lines (15 sublines made resistant to common antiandrogens through long-term passaging) – OH-flutamide G. VCaP OH-flutamide was generated by long-term culture of VCaP cells in androgen depleted media with OH-flutamide, an AR antagonist. These cell lines can be used to study the role of AR signalling and mechanisms of resistance to androgen deprivation therapy and AR targeting agents in CRPC. This cell line is subclone G.
Receptors of note: Androgen receptor
Parental cell line: VCaP
Model description: CRPC model
disease: Cancer
Storage conditions: liquid N2
Growth medium: RPMI1640 + 10% DCC-FCS + 1 uM FLU
References:

Moll JM et al. 2022. Front. Oncol. Jun 13,12:877613. PMID: 35769722

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