Cat. #160434
UM-UC-3 (Human bladder transitional cell carcinoma) cell line
Cat. #: 160434
Unit size: 1x10^6 cells / vial
Availability: 10-12 weeks
Organism: Human
Tissue: Bladder
Disease: Cancer
Model: Tumourigenic cell line
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: H. Grossman ; Anita Sabichi
Institute: University of Michigan
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: UM-UC-3 (Human bladder transitional cell carcinoma) cell line
- Alternate name: UM-UC-3; UM-UC3; UMUC3; University of Michigan-Urothelial Carcinoma-3
- Cancer: Genitourinary cancer
- Cancers detailed: Human bladder translational cell carcinoma
- Research fields: Cancer
- Organism: Human
- Tissue: Bladder
- Disease: Cancer
- Growth properties: Adherent
- Model: Tumourigenic cell line
- Description: UM-UC-3 cell line is derived from a urinary bladder transitional cell carcinoma from a human male. This is a hypertriploid human cell line. The modal chromosome number was 80, occurring in 42% of cells. Tumourigenicity studies in nude mice revealed the UM-UC-3 produced tumours, 1-1.5 cm in diameter in < 3 weeks. UM-UC-3 has large deletions in TP53 and did not show p53 staining. UM-UC-3 was more resistant to adenoviral gene transduction than several of the other cells evaluated. This cell line had intermediate levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested. UM-UC-3 is among a panel of 12 human urothelial cancer cell lines deposited by the University of Michigan.
Handling
- Format: Frozen
- Growth medium: Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37°C in 5% CO2 environment.
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
Related Tools
- Related tools: UM-UC-1 (Human bladder transitional cell carcinoma) cell line ; UM-UC-4 (Human adenocarcinoma lymph node metastasis) cell line ; UM-UC-5 (Human squamous cell carcinoma of the bladder) cell line ; UM-UC-7 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-9 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-10 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-13 (Human...
References
- Thi et al. 2024. Int J Oncol. 65(1):71. PMID: 38847230.
- Roshan et al. 2024. bioRxiv. PMID: 38979253.
- Yamada et al. 2023. Cancer Immunol Immunother. 72(7):2057-2065. PMID: 36795123.
- Maesaka. 2022. Int J Mol Sci. 23(12): 6516. PMID: 35742959.
- Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
- Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
