Cat. #160434
UM-UC-3 (Human bladder transitional cell carcinoma) cell line
Cat. #: 160434
Unit size: 1x10^6 cells / vial
Organism: Human
Tissue: Bladder
Disease: Cancer
Model: Tumourigenic cell line
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: H. Grossman ; Anita Sabichi
Institute: University of Michigan
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: UM-UC-3 (Human bladder transitional cell carcinoma) cell line
- Alternate name: UM-UC-3; UM-UC3; UMUC3; University of Michigan-Urothelial Carcinoma-3
- Cancer type: Bladder cancer
- Cancers detailed: Human bladder translational cell carcinoma
- Research fields: Cancer
- Organism: Human
- Tissue: Bladder
- Disease: Cancer
- Growth properties: Adherent
- Model: Tumourigenic cell line
- Description: UM-UC-3 is a hypotriploid human urothelial carcinoma cell line established from urinary bladder transitional cell carcinoma. This cell line features a modal chromosome number of 80 (~42% of cells) and demonstrates rapid tumorigenicity in vivo. UM-UC-3 was more resistant to adenoviral gene transduction than several of the other cells evaluated. This cell line had intermediate levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested. UM-UC-3 is among a panel of 11 human urothelial cancer cell lines deposited by the University of Michigan.
Handling
- Format: Frozen
- Growth medium: EMEM EBSS + 2mM Glutamine + 0.1mM Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS) + 1.5g/L sodium bicarbonate + 1.0mM sodium pyruvate.
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
- Subculture routine: Split sub-confluent cultures (70-80 %) 1:4 to 1:10 i.e. seeding at 3-5x10,000 cells/cm² using 0.05% trypsin/EDTA; 37°C; 5% CO2
Related Tools
- Related tools: UM-UC-1 (Human bladder transitional cell carcinoma) cell line ; UM-UC-4 (Human adenocarcinoma lymph node metastasis) cell line ; UM-UC-5 (Human squamous cell carcinoma of the bladder) cell line ; UM-UC-7 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-9 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-10 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line
References
- Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236
- Grossman et al. 1986. J Urol. 136(5):953-9. PMID: 3761468
- Cooper et al. 1994. Oncol Res. 6(12):569-79. PMID: 7787250
- Stadler et al. 1996. Urol Res. 24(4):239-44. PMID: 8873383
- Markl et al. 1998. Cancer Res. 58(23):5348-53. PMID: 9850064
- Williams et al. 2002. Genes Chromosomes Cancer. 34(1):86-96. PMID: 11921286
- Davies et al. 2002. Nature. 417(6892):949-54. PMID: 12068308
- Strefford et al. 2002. Cancer Genet Cytogenet. 135(2):139-46. PMID: 12127398
- Williams et al. 2005. Genes Chromosomes Cancer. 43(3):315-28. PMID: 15846775
- Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639
- Park et al. 2008. J Natl Cancer Inst. 100(19):1401-11. PMID: 18812553
- Chiong et al. 2009. J Urol. 181(6):2737-45. PMID: 19375735
- Bignell et al. 2010. Nature. 463(7283):893-8. PMID: 20164919
- Rothenberg et al. 2010. Cancer Res. 70(6):2158-64. PMID: 20215515
- Barretina et al. 2012. Nature. 483(7391):603-7. PMID: 22460905
- Guo et al. 2013. J Pathol. 230(1):17-27. PMID: 23401075
- Ross et al. 2013. PLoS ONE. 8(12):e84411. PMID: 24367658
- Hurst et al. 2014. Eur Urol. 65(2):367-9. PMID: 24035680
- Klijn et al. 2015. Nat Biotechnol. 33(3):306-12. PMID: 25485619
- Yu et al. 2015. Nature. 520(7547):307-11. PMID: 25877200
- Earl et al. 2015. BMC Genomics. 16:403. PMID: 25997541
- Scholtalbers et al. 2015. Genome Med. 7:118. PMID: 26589293
- Masuishi et al. 2016. J Proteomics. 139:77-83. PMID: 26972028
- Masuishi et al. 2016. Data Brief. 7:1302-5. PMID: 27141528
- Iorio et al. 2016. Cell. 166(3):740-54. PMID: 27397505
- Nickerson et al. 2017. Oncogene. 36(1):35-46. PMID: 27270441
- Zuiverloon et al. 2018. Bladder Cancer. 4(2):169-83. PMID: 29732388
- Dutil et al. 2019. Cancer Res. 79(6):1263-73. PMID: 30894373
- Ghandi et al. 2019. Nature. 569(7757):503-8. PMID: 31068700
- Nusinow et al. 2020. Cell. 180(2):387-402.e16. PMID: 31978347
- Goncalves et al. 2022. Cancer Cell. 40(8):835-49.e8. PMID: 35839778
- Maesaka. 2022. Int J Mol Sci. 23(12):6516. PMID: 35742959
- Yamada et al. 2023. Cancer Immunol Immunother. 72(7):2057-65. PMID: 36795123
- Thi et al. 2024. Int J Oncol. 65(1):71. PMID: 38847230
- Roshan et al. 2024. bioRxiv. PMID: 38979253
