Osteopontin null squamous cell carcinoma cell line

Cells derived from a female mouse with cutaneous squamous cell carcinoma (SCC) lacking osteopontin (OPN) gene. Cells contain p53 and H-ras mutations

Contributors

Inventor Institute
Pi-Ling Chang and Yu-Hua Hsieh The UAB Research Foundation
Cat. #: 161802
Cancer types: Skin cancer
Research Fields: Cancer
Organism: Mouse
Tissue: Skin
Gender: Female
Growth properties: Adherent
Primary citation: Hsieh et.al. 2012. Int J Cancer. PMID: 21826648
Product description: Cells derived from a female mouse with cutaneous squamous cell carcinoma (SCC) lacking osteopontin (OPN) gene. Cells contain p53 and H-ras mutations which are common characteristics of SCCs. These cells develop SCC in syngeneic wild-type and OPN-null mice. Cell line is great for studying host-derived OPN at the systemic and tumor microenvironmnet level in the context of extrinsic cancer cell progression in immune-competent mice
Gender: Female
CRISPR: No
Production details: OPN-null and WT mice in 129S6/SvEv background were bred in-house. ONSC cells were derived from an SCC developed in a female OPN-null mouse subjected to two-stage skin carcinogenesis. Cells were maintained in high-glucose, low-calcium DMEM containing 10% fetal bovine serum.
Receptors of note: No
Growth medium: DMEM with 10% fetal bovine serum
References:

Hsieh et.al. 2012. Int J Cancer. PMID: 21826648

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