MET4 SCC Cell Line

Keratinocyte cell line, representing the ultimate metastatic stage in a SCC cancerous transformation.

Contributors

Inventor Institute
Irene Leigh Queen Mary University of London
Cat. #: 153570
Organism: Human
Tissue: Skin
Model: Tumour line
Alternate name: SCC, Keratinocyte
Product description: <span class="excerpt_part">Keratinocyte cell line, representing the ultimate <strong>met</strong>astatic stage in a SCC cancerous transformation. Background and Research Application <strong>MET</strong>4 SCC cell line is derived from a from <strong>met</strong>astatic SCC within left…</span>
Production details: MET4 was derived from a metastatic SCC within the left auxillary lymph nodes that were biopsied
Additional notes: Difference Between Clones All derived from the same individual, but from varying stages in progression of an SCC: invasive, recurrent and, subsequently metastatic. Keratinocyte lines MET1, MET2, MET3 and MET4 were derived, respectively, from an SCC excised from the back of the left hand (MET1), from 2 recurrent SCC arising at the same site in rapid succession (MET2 and 3)and from metastatic SCC within left axillary lymph nodes biopsied following the third excision (MET4).
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: Keratinocyte cell culture media supplemented with 10ng/ml EGF (Long term growth), DMEM/5% serum (Banking purposes)
Biosafety level: 1
References:

Inman et al. 2018. Nat Commun. 9(1):3667. PMID: 30202019.

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

Abikhair Burgo et al. 2018. JCI Insight. 3(17):. PMID: 30185657.

Abikhair Burgo et al. 2018. JCI Insight. 3(17):. PMID: 30185657.

Mekhdjian et al. 2017. Mol Biol Cell. 28(11):1467-1488. PMID: 28381423.

Proby et al. 2000. Exp Dermatol. 9(2):104-17. PMID: 10772384.

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MET4 SCC cell line

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