Cat. #162029
Melan-p1 cell line
Cat. #: 162029
Organism: Mouse
Tissue: Skin
Disease: Ocular Albanism
Model: Immortalised non-cancerous cell lines
£575.00
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Contributor
Inventor: Elena Sviderskaya
Institute: St. George's University London
Primary Citation: Sviderskaya EV, et al. J Invest Dermatol.1997 Jan;108(1):30-4. PMID: 898028
Tool Details
*FOR RESEARCH USE ONLY
- Name: Melan-p1 cell line
- Organism: Mouse
- Tissue: Skin
- Disease: Ocular Albanism
- Morphology: Small, oval-fusiform
- Model: Immortalised non-cancerous cell lines
- Description: The melan-p1 and -p2 cell lines are immortal melanocyte cell lines derived from neonatal Oca2p-cp/Oca2p-25H CH3 mice. These cell lines lack Oca2 (also referred to a p protein), a chloride ion channel found to relate melanosomal pH. Pathogenic variants in the human ortholog of Oca2, OCA2, result in oculocutaneous albinism type 2, a form of albinism characterised by variable hypopigmentation of the skin and hair and ocular defects. Individuals with OCA2 have significantly higher risk of developing skin cancers, including melanoma. These cells are hypopigmented despite the expression of tyrosinase. These cells are a useful model for OCA2 and for use in pigment cell biology studies. Melanoblast lines (melb-p3 and melb-p4) derived from pcp/p25H C3H mice are also available from CancerTools.org.
- Application: Melanocyte cell biology
Applications
- Application: Melanocyte cell biology
Handling
- Storage conditions: liquid N2
References
- Sviderskaya EV, et al. J Invest Dermatol.1997 Jan
- 108(1):30-4. PMID: 898028
