Melan-lnk4a-2 cell line

Melan-Ink4a-2 cells are immortal melanocyte cell lines derived from the skin of neonatal Ink4a–/– C57BL/6J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 161997
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Primary citation: Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20;94(6):446-54. PMID: 11904317
Product description: The melan-Ink4a-1, -2, -3 and -4 cell lines are immortal melanocyte cell lines derived from the skin of neonatal Ink4a–/– C57BL/6J mice. These cells are p16Ink4a-null but Arf-competent. These cells are visibly pigmented and display morphology typical of normal melanocytes. In humans, INK4A is often inactivated in a range of cancers including melanoma. As a result, these melanocytes can be useful in studies focussing on skin cancers and melanomas.
Storage conditions: liquid N2
Growth medium: RPMI + FBS (10%) + TPA (200 nM) + CT (200 pM) + human stem cell factor (hSCF) (10 ng/ml) + endothelin-1 (EDN1) (10 nM)
References:

Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20

94(6):446-54. PMID: 11904317

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