#161997

Melan-lnk4a-2 cell line

Cat. #161997

Melan-lnk4a-2 cell line

Cat. #: 161997

Organism: Mouse

Tissue: Skin

Disease: Non-cancer

Model: Immortalised non-cancerous cell lines

£575.00

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Contributor

Inventor: Elena Sviderskaya

Institute: St. George's University London

Primary Citation: Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20;94(6):446-54. PMID: 11904317

Tool Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Melan-lnk4a-2 cell line
  • Organism: Mouse
  • Gender: Unspecified
  • Tissue: Skin
  • Disease: Non-cancer
  • Morphology: Small, oval-fusiform
  • Model: Immortalised non-cancerous cell lines
  • Description: The melan-Ink4a-1, -2, -3 and -4 cell lines are immortal melanocyte cell lines derived from the skin of neonatal Ink4a–/– C57BL/6J mice. These cells are p16Ink4a-null but Arf-competent. These cells are visibly pigmented and display morphology typical of normal melanocytes. In humans, INK4A is often inactivated in a range of cancers including melanoma. As a result, these melanocytes can be useful in studies focussing on skin cancers and melanomas.
  • Application: Melanocyte cell biology
  • Biosafety level: BSL1

Applications

  • Application: Melanocyte cell biology

Handling

  • Growth medium: RPMI + FBS (10%) + TPA (200 nM) + CT (200 pM) + human stem cell factor (hSCF) (10 ng/ml) + endothelin-1 (EDN1) (10 nM)
  • Storage conditions: liquid N2

References

  • Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20
  • 94(6):446-54. PMID: 11904317