pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
| Institute |
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| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151568 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | IHC ; IP |
| Target: | Trefoil factor 1 (TFF1) also known as pS2/pNR2 Estrogen-regulated protein Ab2 |
| Reactivity: | Human |
| Clone: | PS2GE1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 6.5 kDa |
| Immunogen: | A synthetic 31-mer peptide from the C-terminus of human pS2 protein |
| Target background: | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Williams et al. 1996. Hum Pathol. 27(12):1259-66. PMID: 8958295. Characterization of monoclonal antibodies raised to C-terminal peptides of pS2: a major trefoil peptide and motility factor expressed in adenocarcinomas and regions of mucosal injury. |
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