Cat. #151418
Anti-MCM5 [A2.7A3.F12.A7]
Cat. #: 151418
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Mini Chromosome Maintenance protein5 (MCM5)
Class: Monoclonal
Application: IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: University of Cambridge
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-MCM5 [A2.7A3.F12.A7]
- Research fields: Genetics
- Clone: A2.7A3.F12.A7
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IF ; WB
- Description: Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.
- Immunogen: His-tagged human Mcm5 (amino acids 367582)
- Isotype: IgG2b
Target Details
- Target: Mini Chromosome Maintenance protein5 (MCM5)
- Target background: Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.
Applications
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Rakotomalala et al. 2008. J Biol Chem. 283(42):28729-40. PMID: 18693245.
- Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
- Williams et al. 1998. Proc Natl Acad Sci U S A. 95(25):14932-7. PMID: 9843993.
- Improved cervical smear assessment using antibodies against proteins that regulate DNA replication.