#151418

Anti-MCM5 [A2.7A3.F12.A7]

Cat. #151418

Anti-MCM5 [A2.7A3.F12.A7]

Cat. #: 151418

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Mini Chromosome Maintenance protein5 (MCM5)

Class: Monoclonal

Application: IF ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: University of Cambridge

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-MCM5 [A2.7A3.F12.A7]
  • Research fields: Genetics
  • Clone: A2.7A3.F12.A7
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; WB
  • Description: Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.
  • Immunogen: His-tagged human Mcm5 (amino acids 367582)
  • Isotype: IgG2b

Target Details

  • Target: Mini Chromosome Maintenance protein5 (MCM5)
  • Target background: Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.

Applications

  • Application: IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Rakotomalala et al. 2008. J Biol Chem. 283(42):28729-40. PMID: 18693245.
  • Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
  • Williams et al. 1998. Proc Natl Acad Sci U S A. 95(25):14932-7. PMID: 9843993.
  • Improved cervical smear assessment using antibodies against proteins that regulate DNA replication.