#153390

Anti-ErbB2 [ICR52]

Cat. #153390

Anti-ErbB2 [ICR52]

Cat. #: 153390

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Erb-B2

Class: Monoclonal

Application: IHC

Reactivity: Human

Host: Rat

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Chris Dean

Institute: The Institute of Cancer Research

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-ErbB2 [ICR52]
  • Alternate name: ERBB2; Tyrosine kinase type cell surface receptor HER2
  • Research fields: Cancer;Cell biology;Cell signaling and signal transduction
  • Clone: ICR52
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 77 kDa
  • Reactivity: Human
  • Host: Rat
  • Application: IHC
  • Description: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
  • Immunogen: Paper not available
  • Isotype: IgG2b

Target Details

  • Target: Erb-B2
  • Molecular weight: 77 kDa
  • Target background: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Applications

  • Application: IHC

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Styles et al. 1990. Int J Cancer. 45(2):320-4. PMID: 1689275.
  • Rat monoclonal antibodies to the external domain of the product of the C-erbB-2 proto-oncogene.