DNA ligase 1 is involved in DNA replication and the nucleotide excision repair pathway.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152694 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | WB ; ELISA ; IHC ; IP ; WB |
| Target: | DNA Ligase 1 |
| Reactivity: | Bovine ; Human |
| Clone: | 7A12 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | DNA ligase 1 is involved in DNA replication and the nucleotide excision repair pathway. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 125 kDa |
| Immunogen: | Bovine DNA Ligase I |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | DNA ligase 1 is involved in DNA replication and the nucleotide excision repair pathway. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Liang et al. 2008. Nucleic Acids Res. 36(10):3297-310. PMID: 18440984. Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Prigent et al. 1994. Mol Cell Biol. 14(1):310-7. PMID: 8264597. Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I. |
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